Madlen Löbel, geb. Rother
Nationality: Germany
Organisation: Charité - Universitätsmedizin Berlin
Institute: Institute for Medical Immunology
Address: Augustenburger Platz 1
13353 Berlin
Campus: Charité Campus Virchow-Klinikum
Südstraße 2
E-Mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
Track: Biology Track
At BSRT since: 01.03.2009
Mentoring Committee: Prof. Volk
Prof. Lauster
Prof. Scheibenbogen
CV: 10/2002 to 05/2008
Diploma in Biotechnology at Technische Universität Berlin, Germany.
Title of PhD project: Interaction of the matricellular protein CCN1 with immune cells
Project Abstract: The secreted matricellular protein CCN1/ Cystein-rich protein 61 (Cyr61) is known to play an important role in extracellular matrix (ECM) processes. Several stimuli as growth factors, cytokines but also mechanical stress are able to induce CCN1 expression. The protein is further upregulated in pathological conditions, especially concerning connective tissue and even cancer. Recently, a strong upregulation of CCN1 in patients with virus infection mediated inflammatory Dilated Cardiomyopathy (DCMi) was shown. Here, this PhD-project will deal with the evaluation of the therapeutic potential and immunomodulatory functions of CCN1 in cardiomyopathy.
Publications:

Wilk S, Scheibenbogen C, Bauer S, Jenke A, Rother M, Guerreiro M, Kudernatsch R, Goerner N, Poller W, Elligsen-Merkel D, Utku N, Magrane J, Volk HD, Skurk C. Adiponectin is a negative regulator of antigen-activated T cells. Eur J Immunol. 2011 Aug;41(8):2323-32. doi: 10.1002/eji.201041349 [Pubmed]

Rother M, Krohn S, Kania G, Vanhoutte D, Eisenreich A, Wang X, Westermann D, Savvatis K, Dannemann N, Skurk C, Hilfiker-Kleiner D, Cathomen T, Fechner H, Rauch U, Schultheiss HP, Heymans S, Eriksson U, Scheibenbogen C, Poller W. Matricellular signaling molecule CCN1 attenuates experimental autoimmune myocarditis by acting as a novel immune cell migration modulator. Circulation. 2010 Dec 21;122(25):2688-98 [Pubmed]

Poller W, Rother M, Skurk C, Scheibenbogen C. Endogenous Migration Modulators as Parent Compounds for the Development of Novel Cardiovascular and Antiinflammatory Drugs. Br J Pharmacol. 2011 Oct 28. doi: 10.1111/j.1476-5381.2011.01762.x [Pubmed]
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