Martina Seifert Profile Page
| Organisation: | Charité |
| Institute: | Institute for Medical Immunology |
| Address: | Augustenburger Platz 1 13353 Berlin |
| Campus: | Virchow Klinikum |
| Phone: | +49 30 450 539435 |
| Fax: | +49 30 450 539936 |
| E-Mail: | This e-mail address is being protected from spam bots, you need JavaScript enabled to view it |
| Nationality: | Germany |
| Field: | Immune system |
| Track(s): | Bio;Med |
| CV: | since 2009: Group leader at the Berlin- Brandenburg Center of Regenerative Therapies (BCRT, platform D) 2009: Postdoctoral lecture qualification (Immunology) at the Humboldt-University Berlin, Charité 2007 PI at the Berlin- Brandenburg Center of Regenerative Therapies (BCRT) 2007 Approval as Expert of Immunology Since 1994: Group leader at the Institute of Medical Immunology, Charité Since 1989: Scientific research assistant at the Institute of Medical Immunology, Humboldt-University Berlin, Charité 1989 PhD at the University of Leipzig 1995 Diploma (Immunobiology) at the University Leipzig 1981-1985: Study of Biology at the University of Leipzig 1980-1981: Study of Biochemistry at the University of Halle |
| Research Interests: | The research in my group is mainly focusing on (i) the analysis of immunogeneic and inflammatory characteristics and the immumodulatory capacities of stem cells and their derivatives as well of other primary cell types for potential therapeutic application and (ii) the evaluation of inflammation and immune mediated processes by natural derived extracellular matrix structures. Cell and tissue grafts could be implemented in many fields of regenerative medicine to substitute damaged tissue and to promote the induction of self-renewing processes. Although non-foreign (autologous) cells and tissues are frequently used, several immunological problems arise by to long-term culture periods in vitro as well as by the combination with matrix structures. Due to limited sources for autologous cells and a need for their off-the-shelf availability there is a substantial interest to apply also foreign (allogeneic) cells and tissues. In this scenario rejection problems induced by adaptive immune responses have to be handled. Based on this background we are working at the following research fields: 1. Immunogenicity and immunomodulation of stem cells, their derivatives and other primary cells (e.g. endothelial cells, endothelial progenitor cells, mesenchymal stem cells, cardiac derived progenitor cells, nucleus pulposus cells) 2. Modification of immunogenicity of stem cells and their derivatives (e.g. by modulating their surface molecule expression pattern) 3. Immunomodulation of endothelial cells for application in vascular substitutes and generation of suitable models for testing small caliber vascular grafts 4. Analysis of immunomodulatory and repair function of Mesenchymal Stem cells (MSCs) of different origin and sources by developing a set of in vitro systems, like proliferation, cytotoxicity, complement activation and cytokine/chemokine release assays as well the screening in rat in vivo models 5. Studies on dimension and quality of human immune responses to xenogeneic natural extracellular matrix components |
| Publications: | 1. M. Seifert, B.H. Gruenberg, R. Sabat, P. Donner, G. Gruetz, H.-D. Volk, K. Wolk and K. Asadullah (2003): Keratinocyte unresponsiveness towards Interleukin-10: lack of specific binding due to deficient IL-10 receptor 1 expression. Experimental Dermatology 12: 137-144. 2. Beyer, C. Doebis, A. Busch, T. Ritter, A. Mhashilkar, W.A. Marasco, H. Laube. H.D. Volk, M. Seifert (2004): Decline of surface MHC I by adenoviral gene transfer of anti-MHC I intrabodies in human endothelial cells-new perspectives for the generation of universal donor cells for tissue transplantation. J Gene Med 6: 616-623 3. A. Busch, W.A. Marasco, C. Doebis, H.D. Volk, M. Seifert (2004): MHC class I manipulation on cell surfaces by gene transfer of anti-MHC class I intrabodies - a tool for decreased immunogenicity of allogeneic tissue and cell transplants. Methods 34: 240-249. 4.. C. Doebis, S. Schu, J. Ladhoff, A. Busch, F. Beyer, J. Reiser, R.F. Nicosia, S. Brösel, H.-D. Volk, M. Seifert (2006): An anti-Major Histocompatibility Complex I intrabody protects endothelial cells from an attack by immune mediators. Cardiovascular Research 72: 331-338. 5. A. Zdoroveac, C. Doebis, H. Laube, S. Brösel, I.Schmitt-Knosalla, H.-D. Volk , M. Seifert (2008): Modulation of graft arteriosclerosis in a rat carotid transplantation model. J Surg Research 145: 161-169. 6. J. Ladhoff, M. Bader, S. Brösel, E. Effenberger, D. Westermann, H.D. Volk, M. Seifert (2009): Low immunogenicity of endothelial derivatives from rat embryonic stem cell-like cells. Cell Research 19: 507-518. |
