Andreas Radbruch Profile Page
| Institute: | German Rheumatism Research Center |
| Address: | Charitéplatz 1 10117 Berlin |
| Campus: | Mitte |
| E-Mail: | This e-mail address is being protected from spam bots, you need JavaScript enabled to view it |
| Field: | Cell Biology |
| Track(s): | Bio;Med |
| CV: | since 1998 Professor for Rheumatology at the Charite – Universitatsmedizin Berlin since 1996 Scientific Director of the Deutsches Rheuma-Forschungszentrum Berlin, DRFZ (German Rheumatism Research Center) 1990 - 1998 Associate Professor for Genetics and Immunology, University of Cologne 1988 - 1989 Bayer-Chair at the Institute for Genetics of the University of Cologne 1988 Election to the Faculty of Sciences of the University of Cologne (Habilitation) Teaching licence for “Genetics and Immunology” (Venia Legendi) 1982 - 1988 Assistant Professor, Institute for Genetics of the Cologne University 1980 - 1982 Research Assistant at the Institute for Genetics of the Cologne University 1980 Ph.D. at the Institute for Genetics of the University of Cologne 1976 Diploma in biology at the University of Bonn |
| Research Interests: | A biologist by education, Andreas Radbruch works on the immune system, and the way it provides immunity or participates in immunopathology. In particular, his work aims at a molecular understanding of the control of immune reactions and immunological memory in vaccination, and autoimmune and allergic inflammation. In early work on the regulation of antibody class switching in B lymphocytes, he demonstrated antibody class switch recombination in human memory B lymphocytes and murine antibody secreting plasma cells, demonstrating the role of switch recombination in vivo. He could show that switch recombination is controlled by cytokines from T lymphocytes. Consequently he then focussed on how expression of those cytokines is controlled in T lymphocytes. In recent and ongoing work, his group analyses the molecular basis of expression control of interleukin-4, -10 and interferon-gamma. They have identified a genetic element controlling the imprinting of the interleukin-4 gene for memory expression (Tykocinski et al. Biol Chem. 2005;280(31):28177). Currently, the group is analysing the mechanism of imprinting of cytokine genes in molecular detail. In a broader approach towards a molecular understanding of memory T lymphocytes, the group has identified by transcriptome analysis genes expressed in repeatedly activated T cells, which allow these cells to survive and resist physiological regulation in chronic inflammation. Likewise, the group is working on the biology of plasma cells which confer the humoral immunological memory, i.e. the protection provided by serum antibodies specific for antigens encountered in the past, but also pathogenic antibodies in autoimmunity and allergy. The group developed a new concept of conditional survival of longlived plasma cells (Radbruch et al., Nat Rev Immunol. 2006;(10):741). Both lines of research aim at developing "Cell Therapies" for the targeted elimination of memory T cells and memory plasma cells driving chronic inflammation, allergy and rheumatic diseases, and being resistant to physiological regulation. This strategy is also reflected in the technological developments originating from the group. This group has developed high-gradient magnetic cell sorting (MACS), with Miltenyi Biotech being a spin-off company. Another Biotech company originating from this group is AMAXA, which is developing technologies for the efficient introduction of nucleic acids into primary eukaryotic cells. |
| Publications: | Niesner U, Albrecht I, Janke M, Doebis C, Eulenburg K, Chang HD, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, , Bartfeld S, Radbruch H, Baumgart DC, Duchmann R, Rudwaleit M, Haeupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Radbruch A (2008). Autoregulation of Th1-mediated inflammation by twist1. J. Exp. Med., accepted. Chang H-D, Helbig C, Tykocinski L, Kreher S, Koeck J, Niesner U, Radbruch A Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3 Eur. J. Immunol. (2007), 37, 807-817 Dörner T, Radbruch A (2007). Antibodies and B cell memory in viral immunity. (Review). Immunity 27, 384-392. Odendahl, M, H Mei, BF Hoyer, AM Jacobi, A Hansen, C Berek, F Hiepe, R Manz, T Dörner, A Radbruch. Generation of migratory antigen-specific plasmablasts and mobilisation of resident plasma cells in a secondary immune response. Blood 2005, 105:1614-21 Tykocinski, LO, P Hajkova, HD Chang, T Stamm, O Sözeri, M Löhning, J Hu-Li, U Niesner, S Kreher, B Friedrich, C Pannetier, G Grütz, J Walter, WE Paul, A Radbruch. A critical control element for interleukin-4 memory expression in T helper lymphocytes. J Biol Chem 2005, 280: 28177-185 Hoyer, B.F., K. Moser, A.E. Hauser, A. Peddinghaus, C. Voigt, D. Eilat, A. Radbruch, F. Hiepe, and R.A. Manz. 2004. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J Exp Med 199:1577-1584. Manz RA, A Thiel, A. Radbruch. Lifetime of plasma cells in the bone marrow. Nature 1997. 388:133-4. |
