Andreas Lendlein Profile Page
| Organisation: | GKSS |
| Institute: | Institute of Polymer Research |
| Address: | Kantstraße 55 14513 Teltow-Seehof |
| Campus: | Teltow |
| E-Mail: | This e-mail address is being protected from spam bots, you need JavaScript enabled to view it |
| Field: | Biomaterial Science |
| Track(s): | Eng |
| CV: | since 2006 Vice-Director and Co-ordinator of Research Field “Bio-Engineering”, Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Campus Virchow Charité, Berlin, Germany Member of the faculty board of the medical faculty of Charité, Berlin, Germany since 2003 Speaker of the Research Program: “Regenerative Medicine”, Helmholtz Association of German Research Centers since 2002 Director, Institute of Polymer Research at GKSS Research Center, Campus Teltow, Germany Professor, Materials in Life Sciences, Faculty of Mathematics and Natural Sciences, University of Potsdam, Germany 2004-2006 Director, Institute for Technology and Development, Medical Devices (ITEMP), University of Technology (RWTH) Aachen, Germany Professor, Medical Faculty, University of Technology (RWTH) Aachen, Germany 2002 Postdoctoral Thesis (Habilitation) (Polymer systems with shape-memory properties) in Macromolecular Chemistry, University of Technology (RWTH) Aachen, Germany 1998-2003 Managing director, mNemoscience GmbH, Aachen, Germany 1997-2002 Head of the department, Development and Engineering of Biocompatible Polymer Systems, German Wool Research Institute, University of Technology (RWTH) Aachen, Germany 1997-1998 Visiting Scientist, Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, USA 1996-1997 Postdoctoral Fellow, Department for Material Science, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland 1993-1996 PhD Thesis (Dissertation) (Synthesis and Characterization of Biocompatible and Biodegradable Polymers for Medical Applications), Swiss Federal Institute of Technology (ETH) Zurich, Switzerland, Dr. sc. nat. |
| Research Interests: | The Center for Biomaterial Development in Teltow as a part of GKSS Research Center Geesthacht is member of the German Helmholtz Association, the largest German scientific research organization. In an interdisciplinary and knowledge-based design approach, we develop biomaterials that fulfil the complex requirements for clinical applications in Regenerative Medicine, which include somatic cell therapy, tissue engineering, and induced autoregeneration. Based on these materials we develop (degradable) functional implants, scaffolds as well as controlled factor release systems (e.g. growth factors or cytokines). Our work mainly focuses on three types of polymer systems: - Stimuli-sensitive polymers, with the ability to realize single or multiple stimuli of clinical and biological significance; - Polymer systems based on classical (co) monomers, aiming cell specific compatibility, biofunctionality and degradability; - Biomimetic polymer systems, e.g. obtained from macromonomers based on peptide- and carbohydrate-polymers. Our competences are the computational modelling, and design of biomaterials as well as their further processing into hollow fibres, films, particles, membranes and scaffolds from polymer solution and polymer melt. Furthermore, these materials are analysed with regard to their interaction with physiological environment (in vitro and in vivo). Polymer synthesis together with shape formation, functionalization, and sterilization constitute our technology platform “biomaterial science and bioactive environments”. Multifunctionalization is obtained by physical conditioning, interface engineering and / or loading with bioactive molecules. Besides ophthalmological applications we prioritize the development of medical applications in the musculoskeletal (e.g. bioartificial callus for treatment of critical size bone defect), and cardiovascular area (e.g. small calibre vascular grafts) according to clinical needs. We advance the entire development processes of biomaterial based medical devices to ensure a successful transfer of research and development results into preclinical-/ clinical trials. Hence, we strongly attend national and international cooperations, linking scientific, clinical and industrial partners. Interested PhD students (chemists, biologists, physicians, engineers, veterinary medical scientists) will be able to perform their work in the field of biomaterial science in an interdisciplinary team |
| Publications: | K. Lützow, F. Klein, T. Weigel, R. Apostel, A. Weiss and A. Lendlein: Formation of poly(epsilon-caprolactone) scaffolds loaded with small molecules by integrated processes, Journal of Biomechanics 40 S80-S88 (2007) K. Heilmann, T. Groth, M. Schossig, A. Lendlein and B. Micheel: Modulation of hybridoma cell growth and antibody production by coating cell culture material with extracellular matrix proteins, Biochemical Engineering Journal 35 (3), 301-308 (2007) G. Boese, C. Trimpert, W. Albrecht, G. Malsch, T. Groth and A. Lendlein: Membranes from Acrylonitrile-Based Polymers for Selective Cultivation of Human Keratinocytes, Tissue Engineering 13 (12), 2995-3002 (2007) M. Entrialgo-Castano, A. Lendlein and D. Hofmann: Molecular modeling investigations of dry and two water-swollen states of biodegradable polymers, Advanced Engineering Materials 8 (5), 434-439 (2006) I. Bellin, S. Kelch, R. Langer and A. Lendlein: Polymeric triple-shape materials, Proceedings of the National Academy of Sciences of the United States of America 103 (48), 18043-18047 (2006) W. Albrecht, K. Lutzow, T. Weigel, T. Groth, M. Schossig and A. Lendlein: Development of highly porous microparticles from poly(ether imide) prepared by a spraying/coagulation process, Journal of Membrane Science 273 (1-2), 106-115 (2006) A. Lendlein, H.Y. Jiang, O. Junger and R. Langer: Light-induced shape-memory polymers, NATURE 434 (7035), 879-882 (2005) T. Groth and A. Lendlein: Layer-by-layer deposition of polyelectrolytes - A versatile tool for the in vivo repair of blood vessels, Angewandte Chemie-International Edition 43 (8), 926-928 (2004) A. Lendlein and R. Langer: Biodegradable, elastic shape-memory polymers for potential biomedical applications, SCIENCE 296 (5573), 1673-1676 (2002) |
