Michael Bader Profile Page
| Institute: | Max Delbrück Center for Molecular Medicin |
| Address: | Robert-Rössle-Str.10 13122 Berlin |
| Campus: | Berlin Buch |
| E-Mail: | This e-mail address is being protected from spam bots, you need JavaScript enabled to view it |
| Field: | Molecular Biology |
| Track(s): | Bio;Med |
| CV: | 2003 Prof. in Pharmacology and Toxicology, Charité – Universitätsmedizin Berlin 1997 Habilitation in Pharmacology and Toxicology, Free University Berlin 1995-1998 Vice-Coordinator of the Hypertension Research at the MDC 1994-present Group Leader in the Hypertension Research at the Max-Delbrück- Center for Molecular Medicine (MDC), Berlin-Buch 1989-1993 Research assistant in the lab of Prof. Dr. Detlev Ganten at the Department of Pharmacology and German Institute for High Blood Pressure Research, University of Heidelberg 1989 PhD at the University of Freiburg, Germany 1984 Diploma (Biology) at the University of Freiburg, Germany Professional |
| Research Interests: | The group headed by Michael Bader at the Max-Delbrück-Center for Molecular Medicine (MDC) in Berlin-Buch is interested in the molecular biology and function of hormone systems involved in cardiovascular regulation, such as angiotensin, kinins, natriuretic peptides, and serotonin. The physiological functions of the genes for components of these systems are analysed by the production and analysis of transgenic and knockout mouse and rat models. Using the genetically modified animals, the pathophysiological role of the hormone systems is analyzed in cardiovascular disease models, such as myocardial infarction, and regenerative processes are assessed. Another focus of the group is the study of preimplantation embryos and the establishment and differentiation of embryonic stem cells from mice and rats with the goal to clarify the developmental role of the hormones and to allow gene-targeting technologies in the rat. |
| Publications: | Langenickel T, Buttgereit J, Pagel-Langenickel I, Lindner M, Beuerlein K, Al-Saadi N, Plehm R, Popova E, Tank J, Dietz R, Willenbrock R, Bader M. Cardiac hypertrophy in transgenic rats expressing a dominant negative mutant of the natriuretic peptide receptor B. Proc Natl Acad Sci USA. 2006; 103: 4735-4740 Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M, Clavien P-A. Platelet-derived serotonin mediates liver regeneration. Science. 2006, 312: 104-107 Walther DJ, Peter JU, Winter S, Höltje M, Paulmann N, Grohmann M, Vowinckel J, Alamo-Bethencourt V, Wilhelm CS, Ahnert-Hilger G, Bader M. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell 2003, 115: 851-862. Walther D, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003; 299: 76 Fändrich F, Lin X, Chai GX, Schulze M, Ganten D, Bader M, Holle J, Huang DS, Parvaresch R, Zavazava N, Binas B. Preimplantation-stage stem cells induce allogeneic graft tolerance without supplementary host conditioning. Nat Med 2002; 8:171-178 |
