BSRT Graduate School
BSRT People Faculty
Frauke Zipp
Frauke Zipp
Organisation: Charité - Universitätsmedizin Berlin
Institute: Cecilie-Vogt-Clinic for Neurology
Address: Charitéplatz 1
10117 Berlin
Campus: Charité Campus Mitte
Research Interests: Our overall goal is to translate knowledge of the immune regulation and effector mechanisms in inflammatory mechanisms of the brain into the clinic. Focusing on T cell regulation and neuronal protection mechanisms, we work on clarifying how glial/neuronal cell apoptosis is regulated. In the classical chronic inflammatory disease of the brain, multiple sclerosis, damage to neuronal structures was only recently realized to be a key feature, its mechanisms being far from fully understood. Conversely, in classical neurodegenerative diseases such as Alzheimer´s or in brain insults such as trauma and stroke, inflammatory processes have only recently been appreciated to play significant roles in both damage and protection. To answer our questions, we make use of both T cell and brain slice culture (murine and human) as well as the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, and use various transgenic mice for live imaging with Two-photon-microscopy. Our clinical research aims to better characterize the various disease courses and responses to therapy, unravel differences in pathogenesis, and identify diagnostic/prognostic markers for the disease. The main goal, however, is to develop new therapeutic options. Here, we have characterized some concepts which we are currently testing in the clinic. A network exists efficiently linking clinic, magnetic resonance imaging, and laboratories.
Publications: with BSRT students
Bock M, Brandt AU, Dörr J, Kraft H, Weinges-Evers N, Gaede G, Pfueller CF, Herges K, Radbruch H, Ohlraun S, Bellmann-Strobl J, Kuchenbecker J, Zipp F, Paul F. Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients. Clin Neurol Neurosurg. 2010 Oct;112(8):647-52

Siffrin V, Vogt J, Radbruch H, Nitsch R, Zipp F. Multiple sclerosis - candidate mechanisms underlying CNS atrophy. Trends Neurosci. 2010 Apr;33(4):202-10

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